2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N15885
    12-NBD Stearate 117056-67-4
    12-NBD Stearate is a fluorescent fatty acid analogue. 12-NBD Stearate binds to fatty acid binding protein (FABP) and sterol carrier protein-2 (SCP-2). Overexpressing sterol carrier protein-2 (SCP-2) 15-kDa isoform enhances 12-NBD Stearate transport. 12-NBD Stearate is a tool for microscopic long chain fatty acids (LCFA) uptake and internalization studies.
    12-NBD Stearate
  • HY-N15947
    Trifunctional sphingosine 2089062-80-4
    Trifunctional sphingosine is a clickable sphingoid base derivative. Trifunctional sphingosine can be used to study the biological function of sphingoid bases. Trifunctional lipids may overcome several challenges in interrogating lipid biology: their fast metabolism, their weak and transient (but functionally important) interactions with proteins, and the difficulty in tagging them without disturbing the cellular location.
    Trifunctional sphingosine
  • HY-N16118
    Asperosaponin V 120481-38-1 98%
    Asperosaponin V is an indirect modulator of bone metabolism-related targets (e.g., PI3K/AKT, BMP-2/p38, and ERK 1/2 pathways). Asperosaponin V promotes marrow stromal cell proliferation and induces osteoblast differentiation. Asperosaponin V is promising for research of osteoporosis and fracture healing.
    Asperosaponin V
  • HY-N16177
    Methyl 10(E)-heptadecenoate 369657-02-3 98%
    Methyl 10(E)-heptadecenoate is an unsaturated fatty acid methyl ester (FAME)。
    Methyl 10(E)-heptadecenoate
  • HY-N16193
    2,3-Dihydroxypropyl nonadecanoate 62927-07-5 98%
    2,3-Dihydroxypropyl nonadecanoate is an acylglycerol.
    2,3-Dihydroxypropyl nonadecanoate
  • HY-N16203
    Tri-11(Z)-eicosenoin 80380-39-8 98%
    Tri-11(Z)-eicosenoin is an acylglycerol.
    Tri-11(Z)-eicosenoin
  • HY-N16223
    11(E),13(E)-Octadecadienoic acid 693-73-2 98%
    11(E),13(E)-Octadecadienoic acid is an unsaturated fatty acid methyl ester (FAME)。
    11(E),13(E)-Octadecadienoic acid
  • HY-N16232
    2-ACC 3091880-01-9
    2-ACC (2-α-Carboxy cholestanol) is a cholestanol, is a mutant Sonic Hedgehog protein D46A activator with an EC50 of ～5 μM.
    2-ACC
  • HY-N16241
    8(Z),11(Z),14(Z)-Heptadecatrienoic acid 22324-72-7
    8(Z),11(Z),14(Z)-Heptadecatrienoic acid (Norlinolenic acid) is a fatty acid.
    8(Z),11(Z),14(Z)-Heptadecatrienoic acid
  • HY-N16368
    Methyl cis-9,10-methyleneoctadecanoate 3971-54-8 98%
    Methyl cis-9,10-methyleneoctadecanoate is a fatty ester.
    Methyl cis-9,10-methyleneoctadecanoate
  • HY-N16406
    Auroglaucin 41451-81-4
    Auroglaucin is a potent antioxidant. Auroglaucin shows 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging capacity and superoxide radical scavenging activity with EC50 value of 74.6, 12.3 µM, respectively. Auroglaucin shows low activity for inhibiting the autoxidation of docosahexaenoic acid (DHA).
    Auroglaucin
  • HY-N16431
    NFAT-133 165133-85-7
    NFAT-133 is an aromatic polyketide with immunosuppressive and antidiabetic activity. NFAT-133 activates the AMPK pathway, promoting glucose uptake in L6 muscle fibers, thereby resisting diabetes. NFAT-133 inhibits the transcriptional activity of activated T-cell nuclear factor (NFAT), thereby suppressing the expression of IL-2 and the proliferation of T cells, demonstrating an immunosuppressive effect. NFAT-133 does not exhibit antibacterial activity or cytotoxicity, but it can weaken the production of NO in RAW264.7 cells induced by Lipopolysaccharide (LPS) (HY-D1056).
    NFAT-133
  • HY-N16449
    Arachidonoylmorpholine 166100-34-1
    Arachidonoylmorpholine is a metabolic regulatory molecule related to arachidonic acid metabolism. The level of Arachidonoylmorpholine will increase when the function of the intestinal flora is disrupted. Arachidonoylmorpholine is promising for research of pig gut health, such as post-weaning diarrhea (PWD) in piglets.
    Arachidonoylmorpholine
  • HY-N16468
    Riddelliine N-oxide 75056-11-0
    Riddelliine N-oxide is a hepatotoxic agent. Riddelliine N-oxide is promising for research of liver-related diseases.
    Riddelliine N-oxide
  • HY-N16477
    Ciceritol 88167-26-4
    Ciceritol is a dietary fiber component/prebiotic targeting α-galactosidic linkage oligosaccharides. Ciceritol selectively promotes proliferation of beneficial bacteria like Bifidobacteria. Ciceritol is promising for research of gut microbiota-related diseases (e.g., irritable bowel syndrome, metabolic syndrome).
    Ciceritol
  • HY-N16478
    Echihumiline 174285-73-5
    Echihumiline is an alkaloid targeting hepatic cytochrome P450 enzymes (CYP450). Echihumiline induces DNA cross-linking and oxidative stress in hepatocytes, leading to liver necrosis and fibrosis. Echihumiline is promising for research of liver diseases.
    Echihumiline
  • HY-N16504
    Robipseudin A 1460737-79-4 98%
    Robipseudin A is a geranyl flavonol. Robipseudin A can be isolated from the leaves of Robinia pseudoacacia. Robipseudin A exhibits antioxidant activity in DPPH radical scavenging assay.
    Robipseudin A
  • HY-N16508
    3-Hydroxyphloridzin 30779-02-3
    3-Hydroxyphloridzin (3-Hydroxyphlorizin) is a protein tyrosine phosphatase 1B (PTP1B) inhibitor. 3-Hydroxyphloridzin modulates insulin receptor phosphorylation levels. 3-Hydroxyphloridzin is promising for research of type 2 diabetes.
    3-Hydroxyphloridzin
  • HY-N16513
    Muurol-4-ene-3,8-dione 105181-07-5
    Muurol-4-ene-3,8-dione (Compound 2), a sesquiterpene, is one of the main hepatotoxic components in Eupatorium adenophorum. Muurol-4-ene-3,8-dione has an inhibitory effect on the growth of both the normal human hepatocyte cell L02 and the human hepatocellular carcinoma cell HepG2 with IC50 values of 87.52 and 104.48 μM.
    Muurol-4-ene-3,8-dione
  • HY-N16515
    Dulcisxanthone B 869669-62-5
    Dulcisxanthone B is an antioxidant agent with free radical scavenging against DPPH (IC50 of 0.39 mM) and lipid peroxidation inhibition (IC50 of 024 μM).
    Dulcisxanthone B
Cat. No. Product Name / Synonyms Application Reactivity